Figure 5.

DC and lymphocyte trends in SDLNS of OVA-challenged mice. (A) CD11c⁺ DCs were increased in SDLNs within the first 24 hours of challenge and continued to accumulate over time. (B) There was a progressive decrease in T (CD3⁺) versus B (B220⁺) cells through day 3 of challenge. (C) In addition, there was an early proliferation of CD4⁺CD25⁺ T_regs at day 1, with the proportion of T_regs decreasing thereafter. Data are presented as mean ± SEM of five mice at each time point.

Abbreviations: CD, cluster of differentiation; DC, dendritic cell; OVA, ovalbumin; SDLN, skin-draining lymph node; SEM, standard error of the mean; T_regs, T regulatory cells.