Figure 6.

CD103 (α_E subunit) is upregulated in SDLNS but is not necessary for skin homing. (A) Percent of CD4⁺ T cells (upper) and CD4⁺FoxP3⁺ T_regs (lower) that were positive for CD103, demonstrating progressive upregulation of CD103 expression over time between both populations. Data are presented as mean ± SEM of five mice at each time point. (B) CD103 was expressed on approximately 50% of lesional CD4⁺ cells. CD103 was also expressed on CD8⁺ T cells and a small fraction of DCs (not shown), which accounts for scattered single-positive CD103⁺ cells.

Abbreviations: CD, cluster of differentiation; DC, dendritic cell; SDLN, skin-draining lymph nodes; SEM, standard error of the mean; T_regs, T regulatory cells.