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. Author manuscript; available in PMC: 2014 Jun 1.
Published in final edited form as: Nat Methods. 2013 Oct 6;10(12):1213–1218. doi: 10.1038/nmeth.2688

Figure 2. ATAC-seq provides genome-wide information on chromatin compaction.

Figure 2

(a) ATAC-seq fragment sizes generated from GM12878 nuclei (red) indicate chromatin-dependent periodicity with a spatial frequency consistent with nucleosomes, as well as a high frequency periodicity consistent with the pitch of the DNA helix for fragments less than 200 bp. (Inset) log-transformed histogram shows clear periodicity persists to 6 nucleosomes. (b) Normalized read enrichments for 7 classes of chromatin state previously defined17.