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. Author manuscript; available in PMC: 2014 Dec 15.
Published in final edited form as: Cancer Res. 2013 Oct 29;73(24):7301–7312. doi: 10.1158/0008-5472.CAN-13-1897

Figure 2. YEATS4 is recurrently amplified and overexpressed in NSCLC and is the target of 12q15 amplification.

Figure 2

(A) Comparison of mRNA expression in 83 AC tumors and matched non-malignant tissue from the EDRN (p=0.0092). (B) YEATS4 expression between tumors with gain/amplification and tumors with neutral copy number (p<0.0001). (C) Spearman’s correlation of copy number and expression for tumors with copy number alterations of YEATS4 (r=0.59, p=0.009). Expression values for all plots are in log2 units. (D) RT-qPCR of YEATS4 expression in 18 NSCLC cell lines and non-malignant HBEC cells. (E) Immunoblot of YEATS4 in NSCLC lines with and without amplification of 12q15 with GAPDH as a loading control.