Table 1.
Frequency of YEATS4 gain and amplification across multiple datasets
| Data Set | Histology | Samples with CN (n) |
Gain (n) (>2.3 copies, <5) |
Freq Gain (%) | Amplification (n) (>5 copies) |
Freq Amp (%) | Samples with Expression (n) |
Over- experssion |
Freq OE (%) |
|---|---|---|---|---|---|---|---|---|---|
| BCCRC | AC & SqCC |
169,92 | 28,19 | 16.5,20.1 | 5,2 | 3.0, 2.2 | 35,13 | 11, 4 | 31,30 |
| EDRN | AC | 83 | 18 | 21.7 | 4 | 4.8 | 83 | 15 | 18 |
| GSE25016 | AC & SqCC |
77,155 | 10,22 | 13, 14.2 | 0,1 | 0, 0.6 | N/A | N/A | N/A |
| dbGAP | AC | 354 | 18 | 5.1 | 4 | 1.1 | N/A | N/A | N/A |
| MSKCC | AC | 199 | 21 | 10.6 | N/A | N/A | N/A | N/A | N/A |
| Broad | NSCLC | 473 | 28 | 5.9 | 8 | 1.7 | N/A | N/A | N/A |
| TCGA | AC & SqCC |
277,201 | 19,22 | 6.9,10.9 | 15,6 | 5.4,3.0 | 35,17 | 11, 6 | 32, 35 |
| Sanger lung Lines |
NSCLC & SCLC |
128 | 42 | 32.8 | 1 | 0.78 | N/A | N/A | N/A |
| All Sanger cell lines |
All cancers |
508 | 109 | 21.5 | 8 | 1.5 | N/A | N/A | N/A |