Table 1.
Baseline Data by Group [mean (SD) unless otherwise noted]
| Healthy Controls | Insulin Resistant Subjects | |
|---|---|---|
|
|
||
| Variable | n=14 | n=61 |
| Age (years) | 44.9 (12.3) | 47.7 (10.3) |
| Sex male, n (%) | 9 (64.3) | 36 (59.0) |
| BMI (kg/m2) | 22.9 (1.2) | 32.3 (4.0)c |
| Systolic BP (mmHg) | 112.4 (8.8) | 132.2 (11.5)c |
| Diastolic BP (mmHg) | 68.7 (6.6) | 82.7 (7.4)c |
| Triacylglycerols (mg/dL) | 76.4 (22.4) | 213.0 (81.6)c |
| Total Cholesterol (mg/dL) | 181.2 (30.0) | 203.1 (43.2) |
| HDL-C (mg/dL) | 55.9 (8.6) | 41.7 (8.3)c |
| Non-HDL-C (mg/dL) | 125.3 (28.1) | 161.6 (39.7)b |
| Glucose (mg/dL) | 88.2 (9) | 100.8 (10.8)c |
| Insulin (uU/mL) | 3.2 (1.5) | 14.0 (8.4)c |
| HOMA-IR | 0.7 (0.3) | 3.5 (2.2)c |
| Current Smoker, n (%) | 0 (0) | 5 (8.2) |
| Current statin use, n (%) | 0 (0) | 8 (13.1) |
| LA (% total) | ||
| HDL fraction | 25.4 (3.8) | 24.1 (4.2) |
| LDL fraction | 29.8 (5.4) | 29.3 (4.6) |
| VLDL fraction | 15.4 (3.5) | 20.1 (3.4)b |
| Plasma fraction | 29.6 (0.2) | 27.5 (4.3) |
| AA (% total) | ||
| HDL fraction | 10.3 (1.7) | 11.5 (2.7)a |
| LDL fraction | 7.3 (1.5) | 8.5 (1.9)a |
| VLDL fraction | 3.7 (0.8) | 5.6 (1.6)b |
| Plasma fraction | 8.0 (1.4) | 7.4 (1.8) |
| EPA (% total) | ||
| HDL fraction | 0.8 (0.4) | 0.6 (0.3) |
| LDL fraction | 0.7 (0.4) | 0.5 (0.3) |
| VLDL fraction | 0.3 (0.2) | 0.3 (0.2) |
| Plasma fraction | 0.8 (0.6) | 0.4 (0.2)a |
| DHA (% total) | ||
| HDL fraction | 2.8 (1.0) | 2.3 (0.6) |
| LDL fraction | 1.8 (0.7) | 1.5 (0.4) |
| VLDL fraction | 1.1 (0.7) | 1.3 (0.5) |
| Plasma fraction | 2.1 (0.9) | 1.4 (0.4)a |
| DPA (% total) | ||
| HDL fraction | 0.8 (0.2) | 0.8 (0.2) |
| LDL fraction | 0.5 (0.2) | 0.5 (0.1) |
| VLDL fraction | 0.4 (0.1) | 0.5 (0.1)a |
| Plasma fraction | 0.6 (0.2) | 0.5 (0.1) |
a
p<0.05,
b
p<0.01,
c
p<0.001 when control was compared to healthy controls HOMA-IR, homeostatic model assessment of insulin resistance; LA, linoleic acid; AA, arachidonic acid; EPA, eicosapentaenoic acid; DHA, docosahexaenoic acid; DPA, docosapentaenoic acid