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. Author manuscript; available in PMC: 2015 Mar 15.
Published in final edited form as: Cancer Res. 2014 Jan 30;74(6):1670–1681. doi: 10.1158/0008-5472.CAN-13-0777

Figure #4. Prophylactic vaccination, and survival correlation to CD8(+) and pDC subsets and IL-12 concentrations at vaccine site.

Figure #4

Mice were vaccinated with PLG vaccines 14 days prior to B16-F10 melanoma tumor challenge (105 cells). (A) A comparison of survival in untreated mice (Control) and mice treated with GM-CSF loaded PLG scaffolds (GM-CSF) or with PLG scaffolds loaded with GM-CSF in combination with CpG-ODN (CpG), P(I:C), or MPLA. Plots of the normalized magnitude of (B) CD11c(+)CD8(+) DC infiltration, (C) pDC infiltration at the vaccine site, and (D) local IL-12 concentration versus the percent of animals surviving at Day 100 following B16-F10 melanoma tumor challenge (survival data taken from experimental conditions in (A; red data points) and previously reported data with this system26). r values in B–C represent the linear correlation coefficient between y-axis variables (normalized by baseline levels in control scaffolds) and survival percentage.