Table I.

Selected examples of fluorescent proteins being used in zebrafish cancer models

Fluorescent protein	Cancer type	Transgenic/ mosaic expression	Transplantation Results	Reference
GFP/EGFP	Pancreatic tumors	ptfla-EGFP-kRASG12V, stable line	NA	Park et al., 2008
	B-cell acute lymphoblastic leukemia	Xenopus-elongation- factor l -EGFP-TEL-AML1 and zebrafish-beta-actin- EGFP- TEL-AML1. stable lines	IR transplants	Sabaawy et al., 2006
	Melanoma, lymphoma, hepatocarcinoma, gut carcinoma, RMS	Gt(GFP-H-RASV12), stable line	NA	Santoriello et al., 2009
	Liver tumors induced with DMBA and DBP	Ifabp-GFP, stable line	NA	Lam et al., 2006
	T-cell acute lymphoblastic leukemia (T-ALL)	rag2-EGFP-Myc, mosaic expression, rag2-EGFP-Myc. stable line	IR transplants	Langenau et al., 2003
	Genetic screen for T-cell malignancies	lck-EGFP, stable line	IR transplants	Frazer et al., 2009
	T-ALL drug screen	rag2-EGFP-Myc, mosaic	Syngeneic transplants into adults and 5 dpf larvae	Mizgirev and Revskoy, 2010
	ERMS	rag2-GFP+rag-kRASG12D, mosacis	NA	Langenau et al., 2008
RFP	C8161-RFP labeled melanoma	NA	Xenograft transplants into embryos	Topczewska et al., 2006
	Human U251-RFP glioblastoma	NA	Xenograft transplants into embryos	Geiger et al., 2008; Lally et al., 2007
dsRED/dsREDExpress	T-ALL	rag2-mMyc+rag2-dsRED2. mosaic	Syngeneic transplants	Langenau et al., 2008; Smith et al., 2010
YFP/ zs Ycllow	T-ALL	rag2-mMyc+rag2-zs Yellow, mosaic	Syngeneic transplants	Smith et al., 2010
A mcyan	T-ALL	rag2-mMyc+rag2-Amcyan, mosaic	Syngeneic transplants	Smith et al., 2010