Table 1.

Types of memory deficits observed in genetically modified mice and memory enhancements generated by HDAC inhibition

^aThe different genetically modified mice used to investigate the role of several HAT enzymes in memory and the types of memory found to be impaired in those mice.

^bThe different HDAC inhibitors that have been investigated with regard to their ability to enhance memory and synaptic plasticity.

^cThe different histone residues and the post-translational modification at that residue that have been implicated in being regulated during normal or enhanced memory and synaptic plasticity. These modifications are marked by a box in Figure 1.