Figure 3.

Mean (±SEM) percentages of observations spent freezing during the first 192-sec baseline period in the novel tone test context (A,B), the three test tones (C,D), and the first 256 sec of the context test (E,F) are presented for unpaired controls and trace-conditioned sham, DH, and mPFC lesion animals at each of the surgery times: 1 d post-training and 200 d post-training. Novel context freezing is higher in 200 d surgery animals. Lesions of either DH or mPFC disrupt both trace tone and context fear conditioning, although the magnitude of the attenuation depends upon the training-to-lesion interval.