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. 2014 Mar 19;9(3):e91065. doi: 10.1371/journal.pone.0091065

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© 2014 Muller et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A) Representative recruitment curves. Averaged integrated voltage (uV*s) for the baseline recruitment acquisition from all animals is compared to post-stimulation values at both the 8 and 35-minutes timepoints after rTMS. By 2-way ANOVA, there is a significant reduction in the integrated MEP size following 1 Hz stimulation at both 8-minutes [stimulation effect: F(1,162) = 294.3, p<0.0001; MO effect: F(8,162) = 127.5, p<0.0001; interaction effect: F(8,162) = 25.86, p<0.0001] and the 35-minutes [stimulation effect: F(1,162) = 355.6, p<0.0001; MO effect: F(8,162) = 118.2, p<0.0001; interaction effect: F(8,162) = 27.23, p<0.0001] timepoints. Significance is confirmed by post-hoc t-test from 75–95% MO. Error bars indicate SD. ***p<0.001. (B) MEP changes following 1 Hz rTMS. All values are normalized to sham rTMS control. The difference between active and sham rTMS recruitment curves is significant by 2-way ANOVA at the 8-minute [stimulation effect: F(1,90) = 28.35, p<0.0001] and 35-minutes [stimulation effect: F(1,90) = 30.29, p<0.0001] timepoints. At individual stimulator intensities, using post-hoc t-test, there is a significant suppression at 75, 80, 85 and 90% MO (p<0.01, p<0.001, p<0.01, p<0.05, respectively) at the 8-minutes timepoint, and significant suppression at 75, 80 and 85% MO (p<0.05, p<0.01, p<0.01) at the 35-minutes timepoint. Error bars indicate SD. *p<0.05; **p<0.01; ***p<0.001. (C) Representative MEPs following 1 Hz active or sham rTMS. Ten consecutive MEP sweeps at 55% MO, 100% MT, and 95% MO from one animal per condition, active or sham rTMS, are shown. Baseline traces are followed by MEPs generated at the same MO at the 8-minutes and 35-minutes timepoints.