Figure 3. Genome-wide differences in methylation levels between tumors and reduction mammoplasty samples stratified by location of interrogated CpG locus.

Average methylation levels at loci within CGIs and CGI-shores were consistently higher in tumors compared to normal controls regardless of race (Welch's t-test). Average methylation levels at loci outside of CGIs (i.e. CGI-shelves and open sea) were consistently lower in tumors compared to normal controls regardless of race (Welch's t-test). N, normal (reduction mammoplasty); T, tumor; N.Shelf, “North Shelf”; N. Shore, “North Shore”; S. Shore, “South Shore”; S. Shelf, “South Shelf”.