Figure 4. Genome-wide differences in methylation levels between ER + and ER- tumors stratified by location of interrogated CpG locus.

Average methylation levels at loci within CGIs were higher in ER+ tumors compared to ER- tumors (p < 0.025, Welch's t-test). All other differences were not statistically significant. N, normal (reduction mammoplasty); T, tumor; N.Shelf, “North Shelf”; N. Shore, “North Shore”; S. Shore, “South Shore”; S. Shelf, “South Shelf”.