Skip to main content
. 2014 Mar 19;9(3):e92447. doi: 10.1371/journal.pone.0092447

Table 3. Significantly enriched gene ontology terms detected by FAC in A) up-regulated genes, and B) down-regulated genes.

S. No. GO Term (Fold enrichment) No. of Genes P-Value
A) Up-regulated 1. GO:0005654∼nucleoplasm (1.92) 22 0.0047
2. GO:0031981∼nuclear lumen (1.54) 29 0.0189
3. GO:0031974∼membrane-enclosed lumen (1.45) 35 0.0203
4. GO:0043233∼organelle lumen (1.44) 35 0.0254
5. GO:0070013∼intracellular organelle lumen (1.43) 33 0.0306
6. GO:0005615∼extracellular space (1.91) 17 0.0157
7. GO:0044421∼extracellular region part (1.68) 21 0.0227
8. GO:0004222∼metalloendopeptidase activity (3.85) 5 0.0404
9. GO:0043933∼macromolecular complex subunit organization (1.76) 16 0.037
10. GO:0000280∼nuclear division (2.84) 8 0.0225
11. GO:0007067∼Mitosis (2.84) 8 0.0225
12. GO:0000087∼M phase of mitotic cell cycle (2.79) 8 0.0245
13. GO:0048285∼organelle fission (2.73) 8 0.0272
14. GO:0051301∼cell division (2.39) 9 0.0349
15. GO:0007049∼cell cycle (1.71) 17 0.0384
16. GO:0005819∼Spindle (3.14) 6 0.0418
17. GO:0005875∼microtubule associated complex (3.77) 5 0.043
18. GO:0000278∼mitotic cell cycle (2.11) 10 0.0469
19. GO:0007346∼regulation of mitotic cell cycle (3.09) 6 0.0447
B) Down-regulated 1. GO:0004721∼phosphoprotein phosphatase activity (3.51) 7 0.0146
2. GO:0006470∼protein amino acid dephosphorylation (3.72) 6 0.0224
3. GO:0016311∼dephosphorylation (3.21) 6 0.0387
4. GO:0043292∼contractile fiber (4.06) 6 0.0159
5. GO:0030017∼sarcomere (4.18) 5 0.0312
6. GO:0030016∼myofibril (3.69) 5 0.046
7. GO:0044449∼contractile fiber part (3.63) 5 0.0486
8. GO:0000904∼cell morphogenesis involved in differentiation (3.38) 10 0.0028
9. GO:0000902∼cell morphogenesis (2.55) 11 0.0111
10. GO:0032989∼cellular component morphogenesis (2.29) 11 0.022
11. GO:0031175∼neuron projection development (2.58) 8 0.0355
12. GO:0048666∼neuron development (2.19) 9 0.0529
13. GO:0016049∼cell growth (8.11) 6 0.0008
14. GO:0040007∼growth (3.61) 8 0.0067
15. GO:0008361∼regulation of cell size (3.20) 8 0.0126
16. GO:0032535∼regulation of cellular component size (2.74) 9 0.017
17. GO:0031090∼organelle membrane (1.64) 22 0.0239
18. GO:0031966∼mitochondrial membrane (2.08) 10 0.0506
19. GO:0005874∼microtubule (2.69) 9 0.0186
20. GO:0005856∼cytoskeleton (1.48) 25 0.0445
21. GO:0006796∼ phosphate metabolic process (1.70) 20 0.0251
22. GO:0006793∼phosphorus metabolic process (1.70) 20 0.0251
23. GO:0030424∼axon (3.09) 6 0.0443