Table 3.

Neuropsychological testing.

	Motor Manifesting Carriers	Non-Motor Manifesting Carriers	Non- Carrier Family Members	P Value
Memory and Learning
WRAML Picture Memory	7.2 ± 2.9 [n=26]	9.5 ± 2.1 [n=2]	9.7 ± 2.4 [n=29]	0.010
WRAML Picture Memory Delayed Recognition	7.9 ± 3.2 [n=25]	7.5 ± 0.7 [n=2]	11.0 ± 3.3 [n=29]	0.008
WRAML Design Memory	6.3 ± 2.2 [n=22]	8.5 ± 4.9 [n=2]	10.5 ± 3.1 [n=22]	0.001
WRAML Design Memory Delayed Recognition	6.2 ± 2.6 [n=21]	6.5 ± 2.1 [n=2]	11.4 ± 3.0 [n=22]	<0.001
WRAML Verbal Learning	6.1 ± 2.8 [n=23]	10.0 ± 3.6 [n=3]	9.9 ± 3.1 [n=29]	<0.001
WRAML Verbal Learning Delayed Recall	6.1 ± 3.1 [n=21]	11.0 ± 5.3 [n=3]	9.7 ± 2.8 [n=29]	<0.001
WRAML Verbal Learning Delayed Recognition	7.3 ± 3.7 [n=23]	10.7 ± 3.1 [n=3]	10.2 ± 2.7 [n=29]	0.002
Psychomotor Speed and Attention
Trail Making Test Part A	38.7 ± 9.4 [n=23]	64 ± 22.6 [n=2]	51.7 ± 11.9 [n=29]	<0.001
SDMT-Written	−2.4 ± 0.9 [n=22]	−1.0 ± 2.9 [n=2]	0.4 ± 0.9 [n=29]	<0.001
SDMT-Oral	−1.9 ± 1.2 [n=19]	−1.0 ± 2.4 [n=2]	0.4 ± 0.9 [n=28]	<0.001
Executive Functioning
Trail Making Test Part B	36.7 ± 9.8 [n=21]	37.5 ± 26.2 [n=2]	51.1 ± 11.7 [n=29]	<0.001
COWA Semantic Verbal Fluency	35.2 ± 13.3 [n=18]	45.0 ± 11.1 [n=3]	50.9 ± 9.3 [n=29]	0.005
COWA Linguistic Verbal Fluency	32.9 ± 7.5 [n=17]	39.0 ± 13.1 [n=3]	47.7 ± 10.0 [n=29]	<0.001

Abbreviations: WRAML = Range Assessment of Memory and Learning, Second Edition (WRAML-2); SDMT = Symbol Digit Modalities Test; COWA = Controlled Oral Word Association; n = number of participants able to complete each test.

P values are for comparison of neuropsychological test scores in manifesting carriers versus non-carrier family members calculated under the general linear mixed model using random terms for family and family x genotype-phenotype group.

Values are mean ± standard deviation [n].