Fig. 1.

Representative illustration of voxel placement (white box) centered on caudate (upper panel) and frontal lobe (dorsolateral prefrontal cortex; lower panel) (A). The caudate voxel was placed to maximize coverage of the caudate and to minimize coverage of other nearby structures such as internal capsule and putamen as much as possible. For both the caudate and frontal lobe voxels, percentages of gray and white matter included in the voxel did not differ between HGMC and controls (t-test). Representative spectra obtained from the caudate voxels in control (B) and HGMC (C) subjects. Thick black line indicates fit obtained using LCModel, thick gray line indicates baseline. Labels indicate NAA, creatine (Cr), choline (Cho), myo-inositol (mI), glutamate (Glu), and glutamate+glutamine (Glx).