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. Author manuscript; available in PMC: 2015 Apr 1.
Published in final edited form as: Pain. 2013 Dec 11;155(4):674–684. doi: 10.1016/j.pain.2013.12.009

Figure 4.

Figure 4

Intraplantar (IPLT) botulinum toxin B (BoNT-B) inhibits IPLT formalin-induced cFos expression in the spinal dorsal horn. The plot presents mean ± SEM of number of cFos (+) neurons in the spinal dorsal horn in the L4, L5 and L6 segments. IPLT formalin evokes a unilateral increase in cFos(+) neurons in the ipsi- but not contralateral dorsal horn. This formalin-induced cFos increase was blocked by pretreatment with IPLT BoNT-B (1U) for 1 and 7d but not 4hr and 21d. ** p<0.01 vs. saline; one-way ANOVA. N=3 animals per group with 9-12 spinal cord sections counted per animal.