. Author manuscript; available in PMC: 2015 Apr 1.

Published in final edited form as: Pain. 2013 Dec 11;155(4):674–684. doi: 10.1016/j.pain.2013.12.009

Table 1.

Effects of intraplantar BoNT-B on the ipsilateral side.

Experiment		BoNT-B pretreatment time
Experiment		4hr	1d	7d	21d
VAMP degradation	DRG^b	-	^**	^*	-
VAMP degradation	Spinal cord^b	-	-	-	-
Peripheral release (plasma extravasation)^a		^*	^***	^**	-
formalin	NK1r internalization^a	^*	^**	^**	-
	cFos^a	-	^**	^**	-
	Phase2 flinching^a	-	^**	^**	-
IT capsaicin – NK1r internalization^b			^**
IT SP – cFos (2d BoNT-B pretreatment)^b			^****

“-”, P>0.05

P<0.05

^**

P<0.01

^***

P<0.001

^****

P<0.0001

compared to

saline or the

contralateral side.

“/”, experiment not performed at the indicated time point.