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. Author manuscript; available in PMC: 2015 Apr 1.
Published in final edited form as: Acta Biomater. 2013 Sep 19;10(4):1502–1514. doi: 10.1016/j.actbio.2013.09.008

Figure 7. Fibrin PLLA/PLGA composite gels facilitate graft neovascularization and perfusion.

Figure 7

(A) Low power images of FITC-Dextran (green) and bright-field images highlighting the graft area. (B) Zoom at the graft area revealed intense FITC-Dextran+ neovessels penetration following 10 days postimplantation (left). Histological H&E examination demonstrated neovessels occupied with red blood cells penetrating into the graft area. Quantification of FITC-Dextran+ vessel area penetrating into the graft area (C) as well as calculation of the graft area size (D) revealed that Fibrin + PLLA/PLGA (with or without cells) constructs were most supportive of graft neovascularization and perfusion (n = 3–6). From Lesman A, Koffler J, Atlas R, Blinder YJ, Kam Z, Levenberg S: Engineering vessel-like networks within multicellular fibrin-based constructs, Biomaterials, Copyright © 2011 by Elsevier. Reprinted by permission of Elsevier.