Table 4.
Longitudinal mixed effects model of association of baseline bilateral averaged regional cortical thickness and hallucinations over time, displaying predictors retained in the final model and reference terms (supramarginal gyrus and baseline diagnosis).
| Model: Correlations of predicted values versus actual values of the dependent variable: Pearson r=0.29, r2=0.09, df=2823, p<0.0001 for fixed effects; r=0.81, r 2=0.66, df=2821, p<0.0001 including random terms. | ||||||
|---|---|---|---|---|---|---|
| Predictor | β | 95% CI for β | F | df | p | |
| Supramarginal gyrus | 0.04 | −.03, 0.11 | 1.3 | 1,1340 | 0.25 | |
| Time in study (years) | 0.14 | 0.007, 0.28 | 6.5 | 1,719 | 0.01 | |
| Supramarginal gyrus x time | −0.06 | −0.12, −0.004 | 4.4 | 1,1340 | 0.04 | |
| Baseline Hallucinations | 0.32 | 0.24, 0.39 | 69.9 | 1,1340 | <0.0001 | |
| Baseline Diagnosis | AD | −0.06 | −0.1, −0.009 | 2.7 | 2,760 | 0.07 |
| MCI | −0.01 | −0.04, 0.02 | ||||
| CN | 0 | |||||
| Baseline Diagnosis x time | AD | 0.07 | 0.04, 0.10 | 9.8 | 2,719 | <0.0001 |
| MCI | 0.005 | −0.02, 0.03 | ||||
| CN | 0 | |||||
| Baseline AD dementia symptom duration (years) | 0.01 | 0.002, 0.02 | 6.3 | 1,1340 | 0.01 | |
| Baseline Digit Symbol | −0.002 | −0.003, −0.0007 | 12.3 | 1,1340 | 0.0005 | |
| Baseline Age | −0.003 | −0.004, −0.001 | 10.9 | 1,1340 | 0.001 | |
AD (Alzheimer’s disease), β (partial regression coefficient estimate), CI (confidence interval), CN (clinically normal older), df (degrees of freedom), F (F test statistic), MCI (mild cognitive impairment). x indicates an interaction.