Figure 7.
Lung histology and airway hyperresponsiveness. (A) Lungs recovered from non-immunized HuRfl/fl control mice display normal lung architecture with little inflammation. (B) Lungs from immunized HuRfl/fl control mice display significant inflammation consistent with allergic airway inflammation. (C, D) Lungs from immunized HuR knockout mice have significant lung inflammation consistent with an allergic airway inflammatory response (representative hematoxylin and eosin staining of lungs; n = 3 nonimmunized control mice, n = 5 immunized knockout, and n = 5 immunized control mice). (E) Lung airway resistance in response to methacholine exposure (mean ± SEM of n = 6 mice in each group; two independent experiments; *p < 0.05). N.S., not significant. Scale bars, left panels, 200 μm × 10; right panels; 200 μm × 100.