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. 2014 Mar 19;34(12):4309–4317. doi: 10.1523/JNEUROSCI.4295-13.2014

Figure 6.

Figure 6.

Role of PKC and SNAP-25 in DHPG-induced increases in NMDAR currents of spinally projecting PVN neurons. A, B, Representative traces and summary data showing the effect of chelerythrine on DHPG-induced increases in NMDAR-EPSCs of labeled PVN neurons in WKY rats. C, Histogram showing the distinct effect of DHPG on the amplitude of NMDAR-EPSCs in labeled PVN neurons recorded with intracellular solution containing SBP (20 μm) or the scrambled control peptide in SHRs. Inserts, Representative traces of NMDAR-EPSCs recorded with SBP or the scrambled control peptide included in the pipette solution. NMDAR-EPSCs obtained at different time points are indicated by a–d. D, Summary data showing the effect of including SBP in the recording pipette solution on the basal firing activity of seven labeled PVN neurons in SHRs. Data are presented as means ± SEM. *p < 0.05 compared with respective baseline controls.