Table 2.
[HCO3−]o (mm) | 0 | 0 | |
[HCO3−]p (mm) | 0 | 26 | p value |
Threshold (mV)a | −29 ± 0.2 | −31 ± 0.1 | 0.40 |
AP amplitude (mV)a | 49 ± 0.6 | 53 ± 0.4 | 0.12 |
Half-width (μs) | 784 ± 55 | 768 ± 39 | 0.65 |
fAHP amplitude (mV)a | 8.8 ± 0.1 | 10.5 ± 0.1 | 0.02* |
mAHP area (mV · s)a | −1.12 ± 0.01 | −0.68 ± 0.01 | <0.0001* |
n | 11 | 11 |
Fast AP properties were not significantly affected by [HCO3−]p. However, the area of the mAHP was significantly enhanced in 0 mM [HCO3−]p. Values are mean ± SEM.
aMeasured relative to AP threshold.
*Indicates statistical significance, two-way RM ANOVA.