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. 2014 Mar 20;5:44. doi: 10.3389/fphar.2014.00044

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Copyright © 2014 Amchova, Kucerova, Giugliano, Babinska, Zanda, Scherma, Dusek, Fadda, Micale, Sulcova, Fratta and Fattore.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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OBX rats do not show enhanced dopamine level following acute WIN challenge. (A) Basal extracellular levels (fmol/μl of dialysate, mean ±s.e.m.) of DA in the NAc shell of SHAM (n = 4) and OBX (n = 4) Lister Hooded rats. No significant difference was found between the two groups (One-Way ANOVA, p = 0.45). (B) Effect of an intravenous administration of WIN 0.3 mg/kg on DA release in the nucleus accumbens shell of SHAM (n = 4) and OBX (n = 4) Lister Hooded rats. ^*p < 0.05 and ^*p < 0.01, Two-Way ANOVA followed by Bonferroni's post-hoc test.