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. 2014 Mar 20;5:108. doi: 10.3389/fimmu.2014.00108

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Copyright © 2014 Corcoran, Emslie, Kratina, Shi, Hirsch, Taubenheim and Chevrier.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Oct2 and Obf1: finessing the B cell. Summary of published work and data discussed here, identifying the B cell responses that depend upon Oct2 and Obf1 for their optimal function. Oct2 (red arrow) selectively enables B cells to respond to IL5, a T cell-derived driver of ASC differentiation (45). Obf1 (blue arrow) selectively mediates IL4 driven ASC differentiation, downstream of Stat6. Both Oct2 and Obf1 (green arrows) enable BCR signaling, B cell maturation and indirectly, expression of Slamf1, an important mediator of B cell:T cell interactions during a humoral immune response.