Table 1. Highest-level taxonomy definition for module keys with the average GAST distance for the reported taxonomy and the betweenness centrality score for each module.

Module ID	Module Number	Taxonomy	Average GAST Distance	Module Betweenness Centrality Score
Acidobacteria_03_11260	1	Acidobacteriaceae	0.241	0
Acidobacteria_03_15770	2	Acidobacteriaceae	0.258	0
Acidobacteria_03_18	3	Geothrix	0.003	0
Acidobacteria_03_1982	4	Acidobacteriaceae	0.0165	0
Acidobacteria_03_231	5	Solibacter	0.0531	0
Acidobacteria_03_5976	6	Acidobacteriaceae	0.254	0
Actinobacteria_03_11036	7	Acidimicrobiaceae	0.105	0
Actinobacteria_03_3	8	Actinobacteria	0.0026	0
Actinobacteria_03_4	9	Sporichthyaceae	0.0016	0
Actinobacteria_03_91	10	Micrococcus	0.0031	0
Alphaproteobacteria_03_13239	11	Rhodospirilliaceae	0.281	0
Alphaproteobacteria_03_2014	12	Rickettsiaceae	0.0482	0
Alphaproteobacteria_03_62	13	Caulobacteraceae	0.0052	0
Alphaproteobacteria_03_6621	14	Sneathiella	0.0078	0
Alphaproteobacteria_03_91	15	Pelagibacter	0.0496	0.19
Archaea_03_117	16	Methanomicrobiales	0	0
Archaea_03_17	17	Thermoplasmatales	0.0102	0
Bacteroidetes_03_1296	18	Flexibacter	0.0188	0.07
Bacteroidetes_03_168	19	Croceibacter	0.0236	0.04
Bacteroidetes_03_262	20	Flavobacterium	0.0005	0.04
Betaproteobacteria_03_143	21	Herbaspirillum	0.0827	0.02
Betaproteobacteria_03_51	22	Methyloversatilis	0.0063	0.04
Eukarya_06_1718	23	Pteridomonas	0.023	0
Eukarya_06_1772	24	Chlorogonium	0.023	0
Gammaproteobacteria_03_4	25	Pseudomonas	0.0015	0.1
Planctomycetes_03_726	26	Planctomyces	0.0169	0.04
Verrucomicrobia_03_119	27	Opitutus	0.0077	0.005