Table 2. Top upregulated proteins in cancerous tissues compared with the normal renal parenchyma (ranked by fold change).
| Sr. no. | Protein name | Protein ID | Fold change (log2) cancer vs noncancer | P-value | FDR-adjusted P-value |
|---|---|---|---|---|---|
| 1 |
Integrin β |
tr|B4E0R1|B4E0R1_HUMAN |
5.918997073 |
8.05452E−10 |
2.86278E−09 |
| 2 |
Von Willebrand factor |
UniRef100_P04275 |
3.252970919 |
1.76848E−14 |
2.59377E−13 |
| 3 |
Ectonucleotide pyrophosphatase/phosphodiesterase family member 3 |
UniRef100_O14638 |
3.113004422 |
1.65797E−08 |
4.05426E−08 |
| 4 |
Full-length cDNA clone CS0DI085YI08 of placenta of Homo sapiens |
tr|Q86TV4|Q86TV4_HUMAN |
3.011741403 |
0.023659047 |
0.024837091 |
| 5 |
ADFP protein |
tr|Q6FHZ7|Q6FHZ7_HUMAN |
2.950019975 |
1.12143E−11 |
7.07877E−11 |
| 6 |
Histone H3.1 |
UniRef100_UPI0001D3410D |
2.898432243 |
1.31146E−09 |
4.36579E−09 |
| 7 |
Thymidine phosphorylase |
UniRef100_UPI0000E571B6 |
2.888733547 |
1.32789E−19 |
4.4794E−18 |
| 8 |
Aggrecan core protein |
tr|E7EX88|E7EX88_HUMAN |
2.745397619 |
6.5538E−06 |
9.50207E−06 |
| 9 |
Interferon-γ-inducible protein 16, isoform |
tr|D3DUZ3|D3DUZ3_HUMAN |
2.725425564 |
1.91243E−14 |
2.76483E−13 |
| 10 |
Coronin 1A |
IPI00010133 |
2.717496528 |
3.83009E−15 |
6.68285E−14 |
| 11 |
NNMT protein |
tr|Q6FH49|Q6FH49_HUMAN |
2.713371423 |
1.7417E−09 |
5.64935E−09 |
| 12 |
cDNA FLJ59379, highly similar to haematopoietic lineage cell-specific protein |
tr|B4DQ92|B4DQ92_HUMAN |
2.65230756 |
2.87995E−15 |
5.20448E−14 |
| 13 |
Fatty acid binding protein 7 |
tr|Q9H047|Q9H047_HUMAN |
2.617050396 |
5.83826E−06 |
8.56278E−06 |
| 14 |
Periostin |
tr|B1ALD8|B1ALD8_HUMAN |
2.60827884 |
3.85862E−09 |
1.15609E−08 |
| 15 |
cDNA FLJ52464, highly similar to GTPase, IMAP family member 4 |
tr|B4DWA5|B4DWA5_HUMAN |
2.527846248 |
1.22822E−15 |
2.3452E−14 |
| 16 |
ENO2 protein |
tr|Q6FHV6|Q6FHV6_HUMAN |
2.492047979 |
1.45322E−10 |
6.47865E−10 |
| 17 |
Histone H1.5 |
sp|P16401|H15_HUMAN |
2.436089334 |
3.03607E−16 |
6.98295E−15 |
| 18 |
Insulin-like growth factor binding protein 7 |
tr|B4E1N2|B4E1N2_HUMAN |
2.418191943 |
2.65323E−10 |
1.08269E−09 |
| 19 |
Apoptosis-associated speck-like protein containing a CARD |
sp|Q9ULZ3|ASC_HUMAN |
2.402662738 |
4.75155E−17 |
1.20214E−15 |
| 20 |
cDNA FLJ43948 fis, clone TESTI4014924, highly similar to Homo sapiens cytoplasmic FMR1 interacting protein 1 (CYFIP1), transcript variant 1, mRNA |
tr|B3KWV6|B3KWV6_HUMAN |
2.331192861 |
4.53312E−15 |
7.64586E−14 |
| 21 |
Sialic acid synthase |
sp|Q9NR45|SIAS_HUMAN |
2.23177376 |
1.29297E−07 |
2.51631E−07 |
| 22 |
Annexin A4 |
UniRef100_P09525 |
2.209750305 |
8.41075E−13 |
7.53246E−12 |
| 23 |
6-phosphofructokinase type C |
UniRef100_Q01813 |
2.14408679 |
5.29845E−12 |
3.69795E−11 |
| 24 |
ATP-dependent RNA helicase DDX1 |
tr|A3RJH1|A3RJH1_HUMAN |
2.137678406 |
0.000942011 |
0.001063967 |
| 25 | Adenosine deaminase | tr|F5GWI4|F5GWI4_HUMAN | 2.131392334 | 3.03952E−12 | 2.27852E−11 |
Abbreviations: ADFP=adipose differentiation-related protein; FDR=false discovery rate; NNMT=nicotinamide N-methyltransferase.