Table 3. Top down-regulated proteins in cancerous tissues compared with the normal renal parenchyma (ranked by fold change).
| Sr. no. | Protein name | Protein ID | Fold change (log2) cancer vs noncancer | P-value | FDR-adjusted P-value |
|---|---|---|---|---|---|
| 1 |
Metallothionein |
tr|Q8WVB5|Q8WVB5_HUMAN |
−7.070631065 |
1.06E−14 |
1.68E−13 |
| 2 |
Synaptopodin 2 |
tr|B9EG60|B9EG60_HUMAN |
−5.063445471 |
9.29E−12 |
6.1E−11 |
| 3 |
NADH dehydrogenase (ubiquinone) 1α subcomplex, 8, 19 kDa |
tr|B1AM93|B1AM93_HUMAN |
−3.81124236 |
2.51E−36 |
2.54E−33 |
| 4 |
Ubiquitin carboxyl-terminal hydrolase isozyme L1 |
sp|P09936|UCHL1_HUMAN |
−3.744218547 |
1.11E−21 |
4.86E−20 |
| 5 |
NADH dehydrogenase (ubiquinone) Fe-S protein 6, 13 kDa (NADH-coenzyme Q reductase), isoform CRA_a |
tr|Q6IBC4|Q6IBC4_HUMAN |
−3.686259992 |
3.59E−24 |
2.02E−22 |
| 6 |
L-xylulose reductase |
sp|Q7Z4W1|DCXR_HUMAN |
−3.583275422 |
4.51E−20 |
1.57E−18 |
| 7 |
Non-secretory ribonuclease |
UniRef100_P10153 |
−3.548814593 |
8.25E−10 |
2.92E−09 |
| 8 |
NADH dehydrogenase (ubiquinone) iron–sulphur protein 8, mitochondrial (fragment) |
tr|E9PPW7|E9PPW7_HUMAN |
−3.432935132 |
2.5E−27 |
3.17E−25 |
| 9 |
NADH dehydrogenase (ubiquinone) flavoprotein 2, 24 kDa |
tr|Q6IPW4|Q6IPW4_HUMAN |
−3.413973508 |
8.26E−35 |
4.18E−32 |
| 10 |
Bartter syndrome, infantile, with sensorineural deafness (Barttin) |
tr|Q5VU50|Q5VU50_HUMAN |
−3.35833422 |
3.88E−22 |
1.78E−20 |
| 11 |
Cadherin-16 |
UniRef100_O75309 |
−3.349171259 |
3.13E−27 |
3.52E−25 |
| 12 |
Calbindin 1, 28 kDa, isoform CRA_b |
tr|B2R696|B2R696_HUMAN |
−3.345341765 |
4.53E−11 |
2.33E−10 |
| 13 |
Probable N-acetyltransferase 8 |
sp|Q9UHE5|NAT8_HUMAN |
−3.334487761 |
2.4E−11 |
1.36E−10 |
| 14 |
ATPase, Na+/K+ transporting, β1 polypeptide, isoform CRA_a |
tr|A3KLL5|A3KLL5_HUMAN |
−3.332531661 |
4.34E−26 |
4E−24 |
| 15 |
Sodium/glucose cotransporter |
tr|Q8WY15|Q8WY15_HUMAN |
−3.263975139 |
9.13E−10 |
3.18E−09 |
| 16 |
Fructose-bisphosphate aldolase B |
UniRef100_P05062 |
−3.222229924 |
2.6E−15 |
4.78E−14 |
| 17 |
NADH dehydrogenase (ubiquinone) 1α subcomplex subunit 2 |
UniRef100_O43678 |
−3.21030869 |
7.56E−31 |
2.55E−28 |
| 18 |
D-β-hydroxybutyrate dehydrogenase, mitochondrial |
UniRef100_Q02338 |
−3.116941388 |
7.68E−15 |
1.23E−13 |
| 19 |
Ubiquinone biosynthesis protein COQ9, mitochondria |
UniRef100_O75208 |
−3.110815803 |
1.26E−11 |
7.81E−11 |
| 20 |
Uromodulin, secreted form |
tr|E9PEA4|E9PEA4_HUMAN |
−3.088130282 |
1.78E−17 |
4.87E−16 |
| 21 |
cDNA FLJ60317, highly similar to Aminoacylase-1 (EC 3.5.1.14) |
tr|B4DNW0|B4DNW0_HUMAN |
−3.066759162 |
2.07E−18 |
6.17E−17 |
| 22 |
PDZK1-interacting protein 1 |
IPI00011858 |
−3.053007695 |
8.63E−16 |
1.78E−14 |
| 23 |
NADH dehydrogenase (ubiquinone) iron–sulphur protein 7, mitochondrial |
tr|F5GXJ1|F5GXJ1_HUMAN |
−3.048863326 |
2.46E−30 |
4.98E−28 |
| 24 |
UDP-glucuronosyltransferase 2B7 |
UniRef100_P16662 |
−3.046009696 |
6.41E−09 |
1.78E−08 |
| 25 | Glutathione peroxidase 3 | UniRef100_P22352 | −3.037043306 | 1.02E−13 | 1.08E−12 |
Abbreviation: FDR=false discovery rate.