Table 4. Top pathways enriched in the differentially expressed proteins – results from KOBAS 2.0.
| Sr. no. | Pathways | Database | ID | P-value | FDR (Benjamini and Hochberg)-corrected P-value |
|---|---|---|---|---|---|
| 1 |
Oxidative phosphorylation |
KEGG PATHWAY |
hsa00190 |
0 |
0 |
| 2 |
Valine, leucine and isoleucine degradation |
KEGG PATHWAY |
hsa00280 |
2.54241E−14 |
3.69497E−12 |
| 3 |
Pyruvate metabolism |
KEGG PATHWAY |
hsa00620 |
2.3728E−10 |
2.29897E−08 |
| 4 |
Citrate cycle (TCA cycle) |
KEGG PATHWAY |
hsa00020 |
3.09356E−10 |
2.69758E−08 |
| 5 |
Propanoate metabolism |
KEGG PATHWAY |
hsa00640 |
8.215E−10 |
5.96957E−08 |
| 6 |
Branched-chain amino acid catabolism |
PID Reactome |
500780 |
8.18667E−09 |
5.49137E−07 |
| 7 |
Glycolysis/Gluconeogenesis |
KEGG PATHWAY |
hsa00010 |
4.03624E−08 |
2.514E−06 |
| 8 |
Fatty acid metabolism |
KEGG PATHWAY |
hsa00071 |
7.23503E−08 |
3.94309E−06 |
| 9 |
ATP synthesis |
PANTHER |
P02721 |
4.77073E−07 |
2.4471E−05 |
| 10 |
Respiratory electron transport |
PID Reactome |
500282 |
2.98826E−06 |
0.000137145 |
| 11 |
Butanoate metabolism |
KEGG PATHWAY |
hsa00650 |
4.85495E−06 |
0.000211676 |
| 12 |
Arginine and proline metabolism |
KEGG PATHWAY |
hsa00330 |
1.15415E−05 |
0.000437574 |
| 13 |
Tryptophan metabolism |
KEGG PATHWAY |
hsa00380 |
1.24063E−05 |
0.00045076 |
| 14 |
Alanine, aspartate and glutamate metabolism |
KEGG PATHWAY |
hsa00250 |
9.2847E−05 |
0.003113944 |
| 15 |
PPAR signalling pathway |
KEGG PATHWAY |
hsa03320 |
0.000113691 |
0.003540661 |
| 16 |
Glyoxylate and dicarboxylate metabolism |
KEGG PATHWAY |
hsa00630 |
0.000125436 |
0.003771744 |
| 17 |
Lysine degradation |
KEGG PATHWAY |
hsa00310 |
0.000425581 |
0.010644352 |
| 18 |
Integrin signalling pathway |
PANTHER |
P00034 |
0.000441775 |
0.01070076 |
| 19 |
ECM–receptor interaction |
KEGG PATHWAY |
hsa04512 |
0.000637655 |
0.015027987 |
| 20 |
Pentose and glucuronate interconversions |
KEGG PATHWAY |
hsa00040 |
0.000908772 |
0.020161889 |
| 21 |
Peroxisome |
KEGG PATHWAY |
hsa04146 |
0.001069004 |
0.02273588 |
| 22 |
Cytoskeletal regulation by Rho GTPase |
PANTHER |
P00016 |
0.001258049 |
0.026119495 |
| 23 |
Ascorbate and aldarate metabolism |
KEGG PATHWAY |
hsa00053 |
0.001388723 |
0.026910372 |
| 24 |
Collecting duct acid secretion |
KEGG PATHWAY |
hsa04966 |
0.001388723 |
0.026910372 |
| 25 | Role of mitochondria in apoptotic signalling | PID BioCarta | 100106 | 0.002004916 | 0.038006226 |
Abbreviations: ATP=adenosine triphosphate; ECM=extracellular matrix; FDR=false discovery rate; PPAR=peroxisome proliferator-activated receptor; TCA=tricarboxylic acid.