Table 1. Clinicopathological correlation of RAD21 expression.
| Total n (%) | RAD21 negative | RAD21 positive | P-value (t-test*/χ2-test) | |||
| Median age (range) – years | |
70.3 (29.2–91.2) | 70.4 (17.1–94.6) | 0.22* | ||
|
Gender | ||||||
| Male | 340 (52%) | 159 | 47.70% | 181 | 56.70% | 0.02 |
| Female |
312 (48%) |
174 |
52.30% |
138 |
43.30% |
|
|
Differentiation (grade) | ||||||
| Well | 56 (9%) | 13 | 4.00% | 43 | 14.40% | 0.0001 |
| Moderate | 496 (79%) | 274 | 84.00% | 222 | 74.20% | |
| Poorly |
73 (12%) |
39 |
12.00% |
34 |
11.40% |
|
|
TNM_T | ||||||
| 1 | 47 (7%) | 28 | 8.40% | 19 | 6.00% | 0.01 |
| 2 | 85 (13%) | 50 | 15.00% | 35 | 11.00% | |
| 3 | 313 (48%) | 165 | 49.50% | 148 | 46.40% | |
| 4 |
205 (32%) |
90 |
27.00% |
115 |
36.10% |
|
|
TNM_N | ||||||
| 0 | 373 (57%) | 193 | 58.00% | 180 | 56.40% | 0.75 |
| 1 | 151 (23%) | 80 | 24.00% | 71 | 22.30% | |
| 2 | 100 (15%) | 48 | 14.40% | 52 | 16.30% | |
| NA |
28 (4%) |
12 |
3.60% |
16 |
5.00% |
|
|
TNM_M | ||||||
| 0 | 550 (84%) | 291 | 87.40% | 259 | 81.20% | 0.03 |
| 1 |
102 (16%) |
42 |
12.60% |
60 |
18.80% |
|
|
Histological subtype (mucin producing) | ||||||
| Non-mucinous | 527 (81%) | 265 | 80.10% | 262 | 82.10% | 0.55 |
| Mucinous |
123 (19%) |
66 |
19.90% |
57 |
17.90% |
|
|
KRAS | ||||||
| Wild type | 290 (65%) | 182 | 64.80% | 108 | 66.30% | 0.83 |
| Mutation |
154 (35%) |
99 |
35.20% |
55 |
33.70% |
|
|
BRAF | ||||||
| Wild type | 385 (87%) | 245 | 87.50% | 140 | 86.40% | 0.86 |
| Mutation |
59 (13%) |
35 |
12.50% |
22 |
13.60% |
|
|
CIMP | ||||||
| Low | 362 (85%) | 230 | 85.80% | 132 | 83.50% | 0.62 |
| High |
64 (15%) |
38 |
14.20% |
26 |
16.50% |
|
|
MSI | ||||||
| Low | 382 (86%) | 241 | 86.10% | 141 | 87.00% | 0.89 |
| High |
60 (14%) |
39 |
13.90% |
21 |
13.00% |
|
|
p53 | ||||||
| Baseline | 154 (51%) | 98 | 48.50% | 56 | 49.10% | 0.91 |
| Accumulation |
162 (49%) |
104 |
51.50% |
58 |
50.90% |
|
|
Additional therapy | ||||||
| No adjuvant | 450 (69%) | 235 | 70.60% | 215 | 67.40% | 0.43 |
| Adjuvant | 202 (31%) | 98 | 29.40% | 104 | 32.60% | |
Abbreviations: CIMP=CpG island methylator phenotype; MSI=microsatellite instability.
P-values <0.05 are in bold.