Table 2. Pathological, cytological, and immunohistological features for RET-rearranged cases.
| Histologic pattern | Cytological features | Immunohistochemical results | ||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
No |
Fusion partner |
Predominant |
LEP |
PAP |
ACI |
MPC |
SOL |
Cell type |
Mucin production |
Nuclear inclusion |
SRC |
M-Crib |
RET |
Staining pattern |
TTF-1 |
Napsin A |
PAX8 |
Thyroglobulin |
| 1 |
KIF5B |
MPC |
2 |
3 |
1 |
4 |
0 |
Type II |
+ |
− |
− |
− |
Pos |
C |
Pos |
Neg |
Neg |
Neg |
|
2 |
KIF5B |
LEP |
8 |
2 |
0 |
0 |
0 |
Type II |
− |
+ |
− |
− |
Pos |
C |
Pos |
Pos |
Neg |
Neg |
| 3 |
KIF5B |
ACI |
0 |
1 |
6 |
0 |
3 |
Polygonal |
+ |
− |
− |
− |
Pos |
C |
Pos |
Pos |
Neg |
Neg |
|
4 |
KIF5B |
LEP |
5 |
3 |
1 |
1 |
0 |
Type II |
− |
+ |
− |
− |
Pos |
C |
Pos |
Pos |
Neg |
Neg |
| 5 |
KIF5B |
PAP |
3 |
6 |
0 |
1 |
0 |
Type II |
− |
+ |
− |
− |
Pos |
C |
Pos |
Pos |
Neg |
Neg |
| 6 |
KIF5B |
PAP |
0 |
4 |
2 |
4 |
0 |
Columnar |
+ |
− |
− |
− |
Pos |
C |
Pos |
Pos |
Neg |
Neg |
|
7 |
KIF5B |
ACI |
3 |
2 |
5 |
0 |
0 |
Type II |
+ |
− |
+ |
− |
Pos |
C |
Pos |
Pos |
Neg |
Neg |
| 8 |
KIF5B |
PAP |
1 |
4 |
3 |
0 |
2 |
Columnar |
− |
− |
− |
− |
Neg |
− |
Pos |
Pos |
Neg |
Neg |
| 9 |
KIF5B |
PAP |
1 |
4 |
2 |
3 |
0 |
Columnar |
+ |
− |
+ |
+ |
Neg |
− |
Pos |
Pos |
Neg |
Neg |
| 10 |
KIF5B |
LEP |
8 |
2 |
0 |
0 |
0 |
Type II |
− |
+ |
− |
− |
Neg |
− |
Pos |
Pos |
Neg |
Neg |
| 11 |
KIF5B |
PAP |
2 |
6 |
1 |
1 |
0 |
Type II |
− |
+ |
− |
− |
Pos |
C |
Pos |
Pos |
Neg |
Neg |
|
12 |
KIF5B |
PAP |
3 |
6 |
0 |
0 |
0 |
Type II |
− |
+ |
− |
− |
Pos |
C |
Pos |
Pos |
Neg |
Neg |
| 13 |
KIF5B |
PAP |
4 |
5 |
0 |
0 |
0 |
Type II |
− |
− |
− |
− |
Neg |
− |
Pos |
Pos |
Neg |
Neg |
|
14 |
KIF5B |
LEP |
5 |
4 |
0 |
1 |
0 |
Type II |
+ |
+ |
− |
− |
Pos |
C |
Pos |
Pos |
Neg |
Neg |
|
15 |
KIF5B |
PAP |
0 |
4 |
3 |
3 |
0 |
Type II |
+ |
− |
+ |
+ |
#N/A |
#N/A |
#N/A |
#N/A |
#N/A |
#N/A |
| 16 |
KIF5B |
SOL |
0 |
2 |
3 |
0 |
5 |
Polygonal |
+ |
− |
− |
− |
Pos |
C |
Pos |
Pos |
Neg |
Neg |
| 17 |
KIF5B |
SOL |
1 |
2 |
1 |
1 |
5 |
Polygonal |
+ |
− |
− |
− |
Pos |
C |
Pos |
Pos |
Neg |
Neg |
| 18 |
KIF5B |
PAP |
2 |
3 |
2 |
2 |
1 |
Polygonal |
+ |
− |
+ |
− |
Pos |
C |
Pos |
Neg |
Neg |
Neg |
| 19 |
KIF5B |
LEP |
8 |
0 |
2 |
0 |
0 |
Type II |
− |
+ |
− |
− |
Neg |
− |
Pos |
Pos |
Neg |
Neg |
| 20 |
CCDC6 |
LEP |
5 |
4 |
1 |
0 |
0 |
Type II |
− |
+ |
− |
− |
Neg |
|
Pos |
Pos |
Neg |
Neg |
| 21 |
CCDC6 |
SOL |
0 |
0 |
1 |
0 |
9 |
Polygonal |
+ |
− |
+ |
− |
Pos |
C |
Pos |
Pos |
Neg |
Neg |
| 22 | CCDC6 | SOL | 0 | 1 | 4 | 0 | 5 | Columnar | + | − | + | + | Pos | C | Pos | Pos | Neg | Neg |
Abbreviations: ACI=acinar; C=cytoplasmic; CCDC6=coiled-coil domain containing 6; KIF5B=kinesin family member 5B; LEP=lepidic; M=membranous; M-Crib=mucinous cribriform, MPC=micropapillary; #N/A=not assessed; Neg=negative; PAP=papillary; PAX8=paired box gene 8; Pos=positive; RET=rearranged during transfection; SOL=solid; SRC=signet-ring cell; TTF-1=thyroid transcription factor-1.
Case numbers 2, 4, 7, 12, 14, and 15 were reported previously and have been highlighted in bold.