Table 1. Correlation between neuropilin-1 (NRP1) expression and clinicopathological parameters of patients with pancreatic cancer.
| |
|
NRP1 level |
|
||
|---|---|---|---|---|---|
| Characteristics | All cases | Low | High | χ2 | P-value |
| Total participants |
48 |
26 |
22 |
|
|
|
Age at surgery (years) | |||||
| <60 | 14 | 8 | 6 | 0.003 | 0.958 |
| ⩾60 |
34 |
18 |
16 |
|
|
|
Gender | |||||
| Male | 24 | 13 | 11 | 0.084 | 0.772 |
| Female |
24 |
13 |
11 |
|
|
|
Tumour grade | |||||
| Well | 2 | 1 | 1 | 0.031 | 0.985 |
| Moderately | 44 | 24 | 20 | ||
| Poorly |
2 |
1 |
1 |
|
|
|
Tumour location | |||||
| Head | 40 | 23 | 17 | 0.420 | 0.517 |
| Body/Tail |
8 |
3 |
5 |
|
|
|
Tumour size | |||||
| <40 mm | 29 | 16 | 13 | 0.015 | 0.902 |
| ⩾40 mm |
19 |
10 |
9 |
|
|
|
T factor | |||||
| T1/T2 | 2 | 2 | 0 | 1.812 | 0.404 |
| T3 | 16 | 8 | 8 | ||
| T4 |
30 |
16 |
14 |
|
|
|
Lymph-node metastasis | |||||
| Positive | 35 | 17 | 18 | 0.904 | 0.342 |
| Negative |
13 |
9 |
4 |
|
|
|
Vascular invasion | |||||
| Positive | 12 | 4 | 8 | 1.790 | 0.181 |
| Negative |
36 |
22 |
14 |
|
|
|
Perineural invasion | |||||
| Positive | 24 | 11 | 13 | 0.755 | 0.385 |
| Negative |
24 |
15 |
9 |
|
|
|
Microvessel densitya | |||||
| <25 | 16 | 13 | 3 | 5.549 | 0.018 |
| ⩾25 |
32 |
13 |
19 |
|
|
|
Resection margin | |||||
| Positive | 13 | 7 | 6 | 0.089 | 0.765 |
| Negative |
35 |
19 |
16 |
|
|
|
CEA | |||||
| Normal | 20 | 13 | 7 | 0.959 | 0.327 |
| High |
28 |
13 |
15 |
|
|
|
CA19-9 | |||||
| Normal | 16 | 12 | 4 | 3.032 | 0.082 |
| High | 32 | 14 | 18 | ||
Abbreviation: CEA=carcinoembryonic antigen.
a
Number of vessels per 100 magnification field.