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. 2014 Feb 25;110(6):1497–1505. doi: 10.1038/bjc.2014.80

Figure 4.

Figure 4

Eribulin treatment of MX-1 breast cancer cells in vitro decreases migration and invasiveness capacities. (A) Schematic representation of treatment scheme. (B) Inhibitory effects of eribulin or 5-FU on migration of MX-1 cells, expressed as percent changes in eribulin or 5-FU-treated cells compared with migration seen with untreated control cells. Data represent means±s.e.m. from three independent experiments. *P<0.05 vs vehicle control (Dunnett multiple comparison test). #P<0.05 vs 5-FU 10 μM (the Dunnett multiple comparison test except control). (C) Representative fields in the migration assay ( × 20 magnification). (D) Inhibitory effects of eribulin or 5-FU on invasion of MX-1 cells, expressed as percent changes in eribulin or 5-FU-treated cells compared with invasion seen with untreated control cells. Data represent means±s.e.m. from three independent experiments. *P<0.05 vs vehicle control (Dunnett multiple comparison test). #P<0.05 vs 5-FU 10 μM (the Dunnett multiple comparison test except control). (E) Representative fields in the invasion assay ( × 20 magnification).