Table 1.
Proteins That APE1 Identified as Interacting Partners
| Interactor | Function | Experiment | Author |
|---|---|---|---|
| TCP1 | Chaparone | a | Vascotto (135) |
| PRPF19 | DNA repair, RNA splicing, ubiquitination | ||
| KRT8 | Cytoskeletal | ||
| RPSA | Ribosomal protein | ||
| WDR77 | RNA processing | ||
| TCEB1 | Transcription | a | Kristensen (78a) |
| TWF2 | Cytoskeletal associated | ||
| TXNRD1 | REDOX homeostasis | ||
| ANP32A | RNA processing, transcription | b | Fan (44) |
| SET | Nucleosome, RNA processing | ||
| MDM2 | Cell cycle, ubiquitination | b | Busso (22) |
| RNF4 | Transcription, ubiquitination | b | Hu (62a) |
| TP53 | Cell cycle, transcription, DNA damage response | b | Seemann (116a) |
| NPM1 | Nucleosome, DNA repair | b | Vascotto (135) |
| PRPF19 | DNA repair, RNA splicing, ubiquitination | ||
| WDR77 | RNA processing | ||
| PRDX6 | REDOX homeostasis | ||
| TRAF2 | NF-kappaB signaling | b | Merluzzi (91a) |
| STAT3 | JAK/STAT signaling | b | Gray (51c) |
| EP300 | Transcription | b | Sengupta (117a) |
| ASCL2 | Transcription | ||
| YBX1 | Transcription | ||
| SFPQ | DNA repair, RNA splicing, transcription | c | Havugimana (56a) |
| SNRPD1 | RNA processing | ||
| HIF1A | Hypoxia signaling | d | Carrero (25a) |
| XRCC5 | DNA repair | d | Chung (29b) |
| APP | Platelett and neuronal | d | Olah (100a) |
| EP300 | Transcription | d | Sengupta (117a) |
| XRCC1 | DNA repair | e | Vidal (136a) |
| POLR3D | Transcription | e | Ravasi (105a) |
| HOXC13 | Transcription | ||
| TCF21 | Transcription | ||
| UBE2I | Ubiquitination | e | Yan (148a) |
a
Affinity capture-MS.
b
Affinity capture-Western.
c
Cofractionation.
d
Reconstituted complex.
e
Two-hybrid (adapted from http://thebiogrid.org).
APE1, apurinic/apyrimidinic endonuclease 1.