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. 2010 Apr 28;1(1):23–37. doi: 10.3390/genes1010023

Figure 3.

Figure 3

Comparative analysis of the KCNE1 genomic sequence screened. Basewise conservation scores obtained with the Multiz alignment are plotted against the physical position on chromosome 21 for 31 placental mammals featured in the UCSC Genome Browser. The newly identified V47I mutation maps to the highly conserved KCNE1 transmembrane domain delimited by residues 44 and 60 [61].