Table 1.
Observed allele frequencies for the KCNE1 sequence screened in subjects with chronic tinnitus (N=201). Seven non-monomorphic variants are shaded.
| dbSNP ID | chr21 position | major>minor allelesa | variant amino acid | minor allele frequency in chronic tinnitus | homozygous/heterozygous carriers of the minor allele (pHWE) |
|---|---|---|---|---|---|
| rs28933384 | 35,821,913 | C>T | T7I | 0.000 | - |
| - | 35,821,910 | C>T | A8V | 0.000 | - |
| - | 35,821,904 | C>T | T10M | 0.000 | - |
| - | 35,821,903 | G>A | T10T | 0.000 | - |
| - | 35,821,883 | G>A | W17X | 0.000 | - |
| - | 35,821,874 | C>T | T20I | 0.000 | - |
| - | 35,821,850 | C>T | S28L | 0.000 | - |
| rs17173510 | 35,821,849 | G>A | S28S | 0.002 | 0/1 (0.972) |
| rs17857111 | 35,821,838 | G>A | R32H | 0.000 | - |
| - | 35,821,826 | G>A | R36H | 0.000 | - |
| rs1805127 | 35,821,821 | G>A | G38S | 0.359 | 28/88 (0.498) |
| - | 35,821,794 | G>T | V47F | 0.000 | - |
| (novel) | 35,821,794 | G>A | V47I | 0.002 | 0/1 (0.972) |
| - | 35,821,780-1 | TG>AC | L51H | 0.000 | - |
| rs17173509 | 35,821,778 | G>C | G52A | 0.000 | - |
| - | 35,821,779 | G>A | G52R | 0.000 | - |
| - | 35,821,775 | T>C | F53S | 0.000 | - |
| - | 35,821,774 | C>T | F53F | 0.000 | - |
| rs17173508 | 35,821,771 | C>T | F54F | 0.000 | - |
| - | 35,821,770 | G>A | G55S | 0.000 | - |
| - | 35,821,761 | A>C | T58P | 0.000 | - |
| dbSNP ID | chr21 position | major>minor allelesa | variant amino acid | minor allele frequency in chronic tinnitus | homozygous/heterozygous carriers of the minor allele (pHWE) |
| - | 35,821,757 | T>C | L59P | 0.000 | - |
| - | 35,821,734 | C>T | R67C | 0.000 | - |
| - | 35,821,733 | G>A | R67H | 0.000 | - |
| - | 35,821,727 | A>G | K69R | 0.000 | - |
| - | 35,821,724 | A>T | K70M | 0.000 | - |
| - | 35,821,723 | G>C | K70N | 0.000 | - |
| - | 35,821,712 | C>T | S74L | 0.000 | - |
| - | 35,821,708 | C>T | N75N | 0.000 | - |
| - | 35,821,707 | G>A | D76N | 0.000 | - |
| - | 35,821,693 | C>G | V80V | 0.000 | - |
| - | 35,821,693 | C>T | V80V | 0.000 | - |
| - | 35,821,691 | A>G | Y81C | 0.000 | - |
| - | 35,821,686 | G>A | E83K | 0.000 | - |
| rs1805128 | 35,821,680 | G>A | D85N | 0.007 | 0/3 (0.915) |
| - | 35,821,674 | T>C | W87R | 0.000 | - |
| - | 35,821,641 | C>T | R98W | 0.000 | - |
| rs17853625 | 35,821,615 | C>A | C106X | 0.000 | - |
| - | 35,821,608 | G>A | V109I | 0.000 | - |
| - | 35,821,584 | C>T | Q117X | 0.000 | - |
| - | 35,821,559 | C>T | T125M | 0.000 | - |
| - | 35,821,554 | C>A | P127T | 0.000 | - |
| rs2070357 | 35,821,419 | G>A | - | 0.455 | 42/98 (0.865) |
| rs41314071 | 35,821,411 | A>G | - | 0.045 | 1/16 (0.328) |
| rs41314069 | 35,821,376 | C>A | - | 0.000 | - |
| (novel) | 35,821,347 | C>G | - | 0.003 | 0/1 (0.972) |
| rs41312371 | 35,821,283 | A>C | - | 0.000 | - |
| rs41314807 | 35,821,275 | C>T | - | 0.000 | - |
a all alleles refer to the chr21 minus strand