Table 1.

Overview of Mouse experiments IP0-IP4.

	IP0				IP1			IP2			IP3			IP4
Group	A	B	C	D	1	2	3	A	B	C	A	B	C	A	B	C
	Control to B	24 h	Control to D	48 h	Control	High	Low	Positive control	Pre-treatment	Post-treatment	Positive control	Pre-treatment	Post-treatment	Positive control	Post-treatment	Penicillin treatment
Number of mice	12	12	12	12	2	4	4	5	5	5	5	5	5	5	5	5
Dose volume, mL (inoculum)	0.30	0.30	0.30	0.30	-	0.30	0.30	0.30	0.30	0.30	0.35	0.35	0.35	0.30	0.30	0.30
Inoculum conc., CFU/mL	~107 a				-	6.81 × 107	1.79 × 103	2.23 × 107			1.39 × 107			1.65 × 108
Dose volume, mL (Penicillin dose conc. = 10mg/mL)	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	2 × 0.30
Duration of infection	0–24 h	0–24 h	0–48 h	0–48 h	-	0–72 h	0–72 h	0–72 h	0–72 h	0–72 h	0–72 h	0–72 h	0–72 h	0–72 h	0–72 h	0–72 h
Gal treatment	0	20 h	0	24 h	-	-	-	-	÷24 h	24 h	-	÷24 h	24 h	-	24 h	-
Penicillin treatment	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	24 h and 48 h

^a The exact inoculum concentration was not recorded, but it corresponded approximately to concentrations obtained earlier with the strain incubated under the same growth conditions (i.e., preliminary experiment 2). It was estimated to be in the range of 10⁷ CFU/mL on the basis of this and the observed health status of the infected mice; ^b In IP0, IP1, IP2 and IP4 the dose volume of Gal was 0.3 mL of a Gal solution (0.5 mg/mL, 186 μM), thus representing 0.15 mg of Gal. In IP3 was the dose volume 0.35 mL of a Gal solution of the same concentration, i.e., 0.175 mg.