Table 3.
Demographic and clinical factors associated with outcome at 6-month follow-up
| Factors | Dead* |
Alive with LTBD† |
||||
|---|---|---|---|---|---|---|
| Unadjusted OR (95% CI) | Adjusted OR (95% CI)‡ | P Value in Final Model§ | Unadjusted OR (95% CI) | Adjusted OR (95% CI) ‡ | P Value in Final Model§ | |
| Age (1 yr) | 1.07 (1.04–1.09) | 1.08 (1.05–1.10) | <0.001 | 1.06 (1.03–1.08) | 1.06 (1.04–1.09) | <0.001 |
| Prior cognitive impairment|| | 4.05 (1.20–13.63) | 0.66 (0.16–2.83) | — | 4.51 (1.28–15.81) | 1.35 (0.31–5.85) | — |
| Lived at home before hospital admission | 4.24 (1.83–9.79) | 3.98 (1.39–11.39) | 0.010 | 2.12 (0.85–5.27) | 2.37 (0.78–7.17) | 0.127 |
| Transferred to RCU from NSICU¶ | 1.22 (0.51–2.93) | 1.35 (0.38–4.73) | — | 2.48 (1.01–6.10) | 2.19 (0.64–7.54) | — |
| Charlson Comorbidity Index Score | 1.14 (1.02–1.27) | 1.07 (0.93–1.22) | 0.352 | 0.86 (0.75–0.99) | 0.81 (0.71–0.95) | 0.008 |
| Dependent in ADLs before admission** | 5.28 (2.65–10.54) | 2.30 (0.98–5.41)** | 0.056** | 3.50 (1.68–7.33) | 2.29 (0.94–5.62) | 0.070** |
| Acute Physiology Score of APACHE II | 1.32 (1.22–1.43) | 1.35 (1.23–1.49) | <0.001 | 1.28 (1.18–1.40) | 1.33 (1.20–1.47) | <0.001 |
| > 1 Complication during RCU stay†† | 3.06 (1.50–6.23) | 4.22 (1.63–10.90) | 0.003 | 2.42 (1.12–5.22) | 3.18 (1.19–8.51) | 0.021 |
Definition of abbreviations: ADL = Activities of Daily Living; APACHE II = Acute Physiology and Chronic Health Evaluation II; CI = confidence interval; LTBD = long-term brain dysfunction; NSICU = Neurosurgical Intensive Care Unit; OR = odds ratio; RCU = respiratory care unit.
Odds of being dead at 6 months compared with being alive without LTBD.
Odds of being alive with LTBD compared with being alive without LTBD.
Except where indicated, adjusted for age, sex, race, hospital length of stay, Acute Physiology Score of APACHE II, Charlson Comorbidity Index score, living arrangement before hospital admission, multiple complications during RCU stay.
Final predictor model for 6-month outcomes included age, Acute Physiology Score, Charlson Comorbidity Index score, hospital length of stay, preadmission living arrangement, and more than one complication during RCU stay. We included sex and race despite a nonsignificant P value because of their clinical significance. Similar likelihood ratios can be obtained by substituting preadmission living arrangement with preadmission dependence in ADLs.
History of dementia, decreased level of consciousness, confusion, memory loss, or other cognitive impairment, as reported by family or evidenced in medical records.
Patients from NSICU versus those transferred from all other ICUs.
Because of collinearity, not adjusted for living arrangement before hospital admission.
Binary variable describing patients with one or zero complications (the median number in the population) versus those with more than one complication.