Table 5.

Univariate and multivariate analysis of time to death within 33 days of induction

Variable	Univariate Analysis		Multivariate Analysis
	Hazard Ratio (95% CI)	P Value	Hazard Ratio (95% CI)	P Value
Year of treatment	0.72 (0.56–0.93)	0.01	0.74 (0.57–0.96)	0.02
Age ≥ 60 yr	2.66 (1.47–4.83)	0.001	2.85 (1.49–5.44)	0.001
Type of leukemia
ALL (vs. AML reference)	1.03 (0.48–2.19)	0.95
MDS (vs. AML reference)	0.44 (0.06–3.21)	0.42
Baseline laboratory studies
Hemoglobin, per g/dl	0.95 (0.81–1.11)	0.56
Platelets, per ×103/μL	0.99 (0.98–0.997)	0.009
β2-microglobulin, per mg/L*	1.23 (1.12–1.36)	<0.001
Albumin low, < 3.5 g/dl	3.77 (1.97–7.21)	<0.001
Bilirubin elevated, >1.0 mg/dl	2.55 (1.36–4.81)	0.004
Creatinine elevated, > 1.5 mg/dl	3.74 (1.75–7.96)	0.001	2.31 (1.07–4.99)	0.03
ECOG ≥ 2	5.04 (2.90–8.78)	<0.001	2.23 (1.23–4.03)	0.008
Laminar flow room	0.48 (0.27–0.84)	0.01	0.32 (0.18–0.59)	<0.001
Intensive chemotherapy	0.67 (0.38–1.16)	0.15
Neutropenia (ANC < 500 ×103/μL)†	0.75 (0.40–1.43)	0.39
Pneumonia syndrome*	14.99 (7.46–30.15)	<0.001	12.23 (6.05–24.75)	<0.001

For definition of abbreviations, see Table 4.

^*Data on β₂-microglobulin were only available for 474 patients and were therefore not included in the multivariate model. For all other covariates, n = 801.

^†Time-varying covariate.