Skip to main content
. 2013 Aug 19;11:e001. doi: 10.1621/nrs.11001

Figure 2. AR roles in metabolic syndrome and cardiovascular diseases (CADs).

Figure 2

Total ARKO (T-ARKO) mice displayed a greater extent of metabolic abnormalities including obesity, dyslipidemia, insulin resistance, and leptin resistance compared to Wt mice. The AR roles in various cell types for development of these metabolic abnormalities are deduced from the phenotype observations in neuron-specific ARKO (N-ARKO), hypothalamus-specific ARKO (Hyp-ARKO), hepatocyte-specific ARKO (Hep-ARKO), and adipocyte-specific ARKO (A-ARKO) mice. In CADs, T-ARKO mice have increased atherosclerosis plaque formation, but completely abolished aneurysm development. The AR roles in different cell types for CADs are deduced from observations in myeloid cell-specific ARKO (Myl-ARKO), smooth muscle cell-specific ARKO (SM-ARKO), and endothelial cell-specific ARKO (End-ARKO) mice. An up arrow indicates increase, whereas a down arrow denotes decrease in a metabolic abnormality or CAD symptom compared to Wt mice. The minus sign indicates no significant difference was observed between the specific ARKO and Wt mice.