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A, cells were held at −40 mV. ATP induced only a small outward current. B, P2Y1 agonist (MRS2365, 200 nm) failed to induce hyperpolarization in current clamp mode (I = 0) or activate the outward currents under voltage clamp (HP = −40 mV). C, summary of the effects of ATP and MRS2365 on membrane currents in PDGFRα+ cells of wild-type (WT) and P2ry1−/− mice. Filled arrowheads denote ramp depolarizations. Dotted lines denote 0 pA.
