Figure 9. Titers of wt ZH501 in the serum, liver, spleen and brain of immunized mice.
Five-week-old CD1 mice were intramuscularly immunized with 104 PFU of MP-12, 105 PFU of MP-12, 105 PFU of scMP-12, 105 PFU of VRP or with HBSS. Forty days after vaccination, immunized mice were challenged with 103 PFU of the wt ZH501 strain and virus titers in serum, liver, spleen and brain were determined at 3, 6, 9 and 11 days post-challenge. †, samples were obtained from dead animals; ‡, samples were obtained from moribund animals. Each icon represents a single animal.