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. 2014 Mar 20;8(3):e2744. doi: 10.1371/journal.pntd.0002744

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© 2014 Roberts et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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African populations are characterised by high frequencies of the Cen-B (KIR2DS2∼KIR2DL2, KIR2DL2) and Tel-A (KIR3DS1∼KIR2DS4) haplotypes. Gambian samples, including the P_o specimens and malaria cases cluster together and have some of the highest observed frequencies of Cen-B and Tel-A. The proportions of the total variance explained by the first three principal components were respectively 0.42, 0.28 and 0.11. Footnote to figure 3. NO_TS : Parents from Gambian trachoma families, unaffected, TS : Parents from Gambian trachoma families, affected, GAM_SM : Gambian severe malaria cases, GAM_M : Gambian uncomplicated Malaria cases, GCB : Gambian cord bloods, COM : Comoros, ENG : Equatorial New Guinea, GHA : Ghana, IC : Ivory Coast, MO : Morocco, SEN : Senegal, SA : South Africa, EN6 : England – West Midlands Afro-Caribbean, GUA : Guadaloupe, MAR : Martinique, REU : Reunion, TAF (Trinidad Africans), USAF : USA Californian African Americans.