Table 4. Subset analysis of HLA-C1C2 genotype associations with scarring.
Offspring Genotype | Genotype test HLA-C1/C2 | BH Corrected P | Genotype test HLA-C2/C2 | BH Corrected P | n | Number of events |
Unselected | OR = 2.29 p = 0.0026 | 0.0061 | OR = 3.97 p = 0.000051 | 0.0004 | 636 | 159 |
KIR2DL2 − KIR2DL3 + (Cen-AA) | OR = 1.94 p = 0.08 | 0.120 | OR = 2.00 p = 0.15 | 0.191 | 296 | 74 |
KIR2DL2 + KIR2DL3 + (Cen-AB) | OR = 2.33 p = 0.057 | 0.100 | OR = 5.95 p = 0.0025 | 0.006 | 240 | 60 |
KIR2DL2 + KIR2DL3 − (Cen-BB) | OR = 1.5 p = 0.73 | 0.786 | OR = 6.00 p = 0.13 | 0.182 | 76 | 19 |
KIR3DL1 + KIR3DS1 − KIR2DS1 − (Tel-AA) | OR = 2.86 p = 0.0013 | 0.006 | OR = 4.89 p = 0.00006 | 0.0004 | 524 | 131 |
KIR3DS1 + and/or KIR2DS1 + (Tel-Bx) | OR = 0.52 p = 0.29 | 0.338 | OR = 0.90 p = 0.89 | 0.890 | 88 | 22 |
Affected cases defined by more severe scarring (WHO FPC score C2 or C3) & KIR2DL2 + KIR2DL3 + (Cen-AB) | OR = 2.07 p = 0.026 | 0.052 | OR = 3.57 p = 0.0017 | 0.006 | 444 | 111 |