Figure 5. Effects of inhibition of ERK, Akt, PKA, CREB and GPRC6A on the proliferation of l-arginine-treated fibroblasts.

Fibroblast proliferation was measured by MTS assay after pretreatment with 0 or 6l-arginine and subsequent treatment with 10 μM U0126, LY294002, H-89, siRNA CREB and siRNA GPRC6A. Results are expressed as the mean ± SEM of 3 independent experiments.