. 2014 Mar 20;9(3):e92371. doi: 10.1371/journal.pone.0092371

Table 3. Cytokine production by TIM-3 positive and negative CD8+ T, CD56dim and CD56bright NK cells.

		Non-pregnant			1^st trimester			2^nd trimester			3^rd trimester
	pg/ml	TIM-3+	TIM-3-	p	TIM-3+	TIM-3-	p	TIM-3+	TIM-3-	p	TIM-3+	TIM-3-	p
CD56	IL-2	9,18	117,18	NS	9,53	62,95	<0,04	9,25	17,17	<0,01	9,23	80,71	NS
dim	TNF-α	1625,01	2157,81	NS	1820,63	2278,48	NS	104,75^**	793,57	NS	439,75^**	403,62	NS
cells	IFN-γ	2010,29	2172,1	NS	3095,85	3516,78	NS	218,03^**	1095,87	NS	816,23^***	696,77^$	NS
	IL-17	<min	<min	NS	<min	<min	NS	<min	<min	NS	<min	<min	NS
CD56	IL-2	20,97	114,27	NS	13,25	39,99	NS	14	12,78	NS	12,93	50,89	NS
dim	TNF-α	1211,37	1786,06	NS	1036,76	1315,13	NS	641,82	461,83	NS	1188,97	1046,67	NS
cells	IFN-γ	1961,81	3513,19	NS	2656,23	2543,13	NS	1632,29	979,18	<0,04	1894,9	2136,18	NS
	IL-17	<min	<min	NS	<min	<min	NS	<min	<min	NS	<min	<min	NS
	IL-2	3076,06	6400,32	<0,05	2463,73	7812,88	<0,01	687,87	1276,9^*	NS	2587,58	7471,57	<0,03
CD8	TNF-α	1385,92	6064,46	<0,01	1217,89	6654,4	<0,01	356,7	1468,89^$	NS	861,61	3427,65	<0,01
T cells	IFN-γ	3455,09	5750,34	NS	4223,87	6306,06	<0,05	908,5^$$$	2093^$$	NS	2364,49	4851,96	<0,04
	IL-17	17,33	345,2	<0,04	16,93	247,9	<0,05	9,83	11,49	NS	20,83	257,01	<0,04

Statistical comparisons were made by using the ANOVA tests. The results were expressed as the mean value. Differences were considered significant when the value of p was equal to or less than 0.05. NS = not statistically significant.

*Sig. from NP;1st; 3rd (p<0,01).

**Sig. from NP;1st (p<0,01).

***Sig. from NP (p<0,05);1st (p<0,01).

$Sig. from 1st (p<0,01).

$$Sig. from 1st (p<0,04).

$$$Sig. from NP (p<0,03);1st (p<0,05).