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. 2014 Mar 20;9(3):e92715. doi: 10.1371/journal.pone.0092715

Figure 6. Effect of adenosine on lymphatic vasculature and inflammatory cell recruitment in the liver.

Figure 6

Control adenovirus expressing GFP (CTRL virus) or adenovirus carrying the sequence of 5-nucleotidase (cN-IA virus) were injected in the caudal vein of mice. PBS was used as negative control (PBS). Mice were sacrificed 2 weeks after injection. The efficacy of virus transduction was shown by GFP immunostaining (a) and by cN-IA immunostaining (b)). Liver sections were stained with anti-podoplanin antibodies to detect lymphatic vessels (c), with anti-CD45 antibodies to detect inflammatory cells (d), and with anti-F4/80 antibodies to detect macrophages (e). Data are presented as mean ± SEM (n = 15 for PBS, n = 13 for GFP and n = 12 for cN-IA).**p<0.01, *** p<0.001. Representative pictures are shown.