Table 2.

SNPs in relation to pigmentation and melanoma in the Parkinson’s Genes and Environment Study

CHR	Gene	SNP	Minor allele	MAF	Hair color (black to red)			Eye color (blue to black)			Skin color (light to dark)			Melanoma
					beta	s.e.	P	beta	s.e.	P	beta	s.e.	P	OR (95%CI)	P
6	IRF4	rs12203592	T	0.17	−0.26	0.04	1.67×10−10	−0.14	0.05	1.02×10−2	−0.1	0.02	1.51×10−5	2.49 (0.77-0.83)	1.55×10−1
11	TYR	rs1126809	A	0.27	0.07	0.03	4.52×10−2	−0.15	0.05	1.15×10−3	−0.09	0.02	1.22×10−5	1.22 (0.45-3.33)	7.47×10−1
11	TPCN2	rs35264875	T	0.17	0.05	0.04	2.08×10−1	−0.06	0.05	2.39×10−1	0.00	0.02	8.52×10−1	1.73 (0.58-5.22)	3.54×10−1
11	TPCN2	rs3829241	A	0.38	0.09	0.03	6.44×10−3	−0.09	0.04	3.86×10−2	−0.05	0.02	1.09×10−2	0.55 (0.18-1.69)	2.62×10−1
12	KITLG	rs12821256	C	0.09	0.10	0.05	7.28×10−2	0.08	0.07	2.76×10−1	−0.03	0.03	2.68×10−1	1.26 (0.29-5.23)	7.81×10−1
14	SLC24A4	rs12896399	T	0.43	0.2	0.03	1.07×10−10	−0.2	0.04	7.11×10−7	−0.05	0.02	6.53×10−3	0.56 (0.22-1.40)	1.86×10−1
16	MC1R	rs1805008	T	0.07	0.39	0.06	1.60×10−9	−0.08	0.08	3.34×10−1	−0.14	0.04	1.11×10−4	3.79 (0.57-25.06)	2.20×10−1
16	CDK10	rs258322	T	0.10	0.34	0.05	2.00×10−10	0.01	0.07	8.32×10−1	−0.16	0.03	1.24×10−7	1.35 (0.31-5.95)	7.41×10−1
20	ASIP	rs1015362	A	0.28	−0.06	0.03	7.59×10−2	0.00	0.05	9.85×10−1	0.01	0.02	7.96×10−1	4.74 (1.24-18.2)	2.20×10−2
20	ASIP	rs4911414	T	0.33	0.01	0.03	7.19×10−1	−0.05	0.04	2.75×10−1	−0.04	0.02	4.22×10−2	1.97 (0.75-5.18)	1.90×10−1
20	PIGU	rs910873	A	0.07	0.18	0.06	2.53×10−3	−0.06	0.08	4.17×10−1	−0.13	0.03	1.90×10−4	0.55 (0.09-3.35)	5.12×10−1

Adjusted for year of birth and sex.