Table 4.

SNPs in relation to Parkinson’s disease in the Parkinson’s Genes and Environment Study and in the International PD Genomic Consortium

			Parkinson’s Gene Environment Study						International PD Genomic Consortium **
CHR	Gene	SNP	Minor allele	MAF in controls	Case	Control	Adjusted OR (95%CI)*	P *	Meta OR (95%CI)	meta_P
6	IRF4	rs12203592	T	0.16	25/222/539	54/404/1107	1.05 (0.89-1.23)	0.555	0.88 (0.80-0.96)	0.004
11	TYR	rs1126809	A	0.27	62/282/399	123/572/799	1.01 (0.88-1.16)	0.910	1.01 (0.95-1.07)	0.816
11	TPCN2	rs35264875	T	0.17	21/236/526	47/438/1070	1.04 (0.88-1.22)	0.640	0.98 (0.91-1.05)	0.586
11	TPCN2	rs3829241	A	0.38	106/363/302	221/716/601	0.99 (0.87-1.12)	0.825	0.99 (0.94-1.04)	0.615
12	KITLG	rs12821256	C	0.09	10/125/647	22/250/1287	1.00 (0.82-1.23)	0.982	1.02 (0.94-1.11)	0.666
14	SLC24A4	rs12896399	T	0.43	154/368/248	283/746/499	1.04 (0.92-1.17)	0.576	1.00 (0.95-1.05)	0.926
16	MC1R	rs1805008	T	0.06	7/99/671	6/188/1356	1.14 (0.89-1.44)	0.295	0.98 (0.89-1.07)	0.624
16	CDK10	rs258322	T	0.09	8/134/633	22/247/1264	1.03 (0.84-1.27)	0.764	1.10 (1.01-1.20)	0.030
20	ASIP	rs1015362	A	0.29	61/265/432	137/618/789	0.84 (0.73-0.96)	0.011	1.04 (0.98-1.10)	0.195
20	ASIP	rs4911414	T	0.35	86/302/395	190/700/660	0.80 (0.70-0.91)	0.001	1.02 (0.97-1.08)	0.374
20	PIGU	rs910873	A	0.08	5/87/653	8/221/1305	0.82 (0.64-1.05)	0.120	0.90 (0.82-0.99)	0.039

^*Adjusted for year of birth, sex, smoking status and caffeine intake.

^**Other SNPs from the IPDGC were not statistically significantly associated with PD risk.