Skip to main content
. Author manuscript; available in PMC: 2015 Jun 1.
Published in final edited form as: Neurobiol Aging. 2013 Dec 5;35(6):1309–1317. doi: 10.1016/j.neurobiolaging.2013.11.030

Table 3.

Results of multiple regression analyses: associations between ApoE-ε4 genotype and ventricular expansion at 24-month follow-up, within diagnostic groups

CON group only1 MCI group only2 AD group only3
24-month N=156 N=222 N=101
Total expansion (cubic mm) 4,5F-ratio=3.291 F-ratio=6.136 F-ratio=2.552
p=0.040 p=0.003 p=0.083
Left expansion rate F-ratio=4.502 F-ratio=10.573 F-ratio=3.863
p=0.013 p<0.001 p=0.024
Right expansion rate F-ratio=3.843 F-ratio=9.524 F-ratio=3.733
p=0.024 p<0.001 p=0.027
1

The number of ApoE-ε4 alleles (0, 1, or 2) was used to predict variations in ventricular expansion in healthy elderly only, with age and sex regressed out.

2

The number of ApoE-ε4 alleles was used to predict variations in ventricular expansion in the MCI group only, with age and sex regressed out.

3

The number of ApoE-ε4 alleles was used to predict variations in ventricular expansion in AD patients only, with age and sex regressed out.

4

In multiple regressions, the F-ratio is used to test the hypothesis that the slopes of the regression lines are 0. The F is large when the independent variable helps to explain the variation in the dependent variable, independently of the other explanatory variables that are regressed out. For instance, here reject the hypothesis that the slope of the regression line is 0 (F-ratio=3.291, p=0.040), meaning that there is a significant linear relation between the number of ApoE-ε4 alleles carried and total ventricular expansion at 24-month follow-up within the control group, after controlling for age, sex, and diagnosis.

5

Bold font indicates significant results (p<0.05), and regular font indicates results that did not reach statistical significance.